【摘要】 应用脑组织推挽灌流技术结合放射酶学测定法和脑内微量注射法,观察针刺镇痛时清醒家兔视前区去甲肾上腺素(NE)释放量的变化,以及微量注射α受体拮抗剂酚妥拉明对针刺镇痛的影响,探讨该部位NE在针刺镇痛中的作用。实验结果,针刺镇痛时视前区NE释放显著减少;双侧微量注射酚妥拉明(5μg/每侧)可显著加强针刺镇痛作用。结果提示,视前区NE可能通过α受体对抗针刺镇痛。更多还原

【Abstract】 Push-pull perfusion technique and radioenzymatic assay were used to observethe change of norepinephrine (NE) released from the hypothalamic preoptic areaof conscious rabbits during acupuncture analgesia (AA). It was found that NElevel in the perfusate of the preoptic area was markedly decreased during AA (P<0. 01). The effect ofα-antagonist phentolamine (5μg/unilateral) microinjected intothe preoptic area on AA was observed. The result showed that after acupuncturethe pain threshold of the phentolamine plus acupuncture group was raisedsignificantly as compared with that of saline control group (P<0. 05). The results suggest that the activation of α-receptor of the preoptic area exertsan antagonistic influence on AA.更多还原