【摘要】 给7只家兔使用两种炎痛喜康栓剂和一种片剂,用HPLC法研究这两种剂型的相对生物利用度。结果显示:栓剂的药-时曲线下面积(AUC)与片剂没有显著差异,位C_m较片剂高。体内吸收％与体外溶出％有良好的相关性。更多还原

【Abstract】 Piroxicam, a nonsteroidal anti-inflammatory drug, was incorporated into two suppository bases, a fatty acid ester base (FB) and a polyethylene glycol base (PEG) for rectal administration, to avoid gastro-intestinal damage by the oral route. The AUO of piroxioam with PEG 20mg suppositories in rabbits analysad by HPLO method, was 59, and 67μg·h/ml for FB 20mg suppositories. The AUC was 61μg·h/ml when an equal oral dose of the tablet was used as a control. The absorption extent of piroxicam was of no significant difference, however, the Om of suppositories were higher than that of tablet.It was found that statistically significant correlations existed between the % of in vitro release, and the % of in vivo absorption of the two suppositories.更多还原