【摘要】 吡喹酮按总剂量40mg/kg顿服,一次冲击疗法治疗52例慢性血吸虫病(慢血),服药后3～6个月粪检累计阴转率为92.3％。40mg/kg顿服的29例患者血药峰值为2.46±0.22μg/ml,35mg/kg顿服31例患者的血药峰值为1.66±0.10μg/ml。实验动物单剂量吡喹酮40mg/kg组的雌虫减少率为95.12％。根据临床和动物实验建议吡喹酮剂量可改为40mg/kg顿服,使用安全、简便。更多还原

【Abstract】 A bolus dose of praziquantel(pyquiton) 40 mg/kg was given in the treatment of 52 cases of chronic schistosomiasis. Stool examinations were negative in 92.3%, 3 to 6 months after treatment.In another 29 cases (receiving 40 mg/kg in a single dose), blood cone, of the drug was determined and found to be 2.46±0.22μg/ml(mean plasma Omax).While in 31 cases given 35 mg/kg body weight, the mean plasma Omax value was 1.66± 0.10μg/ml. Experimental observation on infected rabbits showed: 40mg/kg caused 95.2% reductions of female adult worms. Based on the above clinical and experimental data, a reduction of the total dose of treatment from the currently used 60mg/ kg in 2 days to 40 mg/kg in one bolus dose is recommended for most patients.更多还原