【摘要】 以大剂量城市悬浮颗粒物(SP)经气管染毒叙利亚仓鼠,并追踪观察其肺损伤变化。仓鼠染毒SP 15mg/kg后3及6个月,肺灌洗液(BAL)的细胞和生化组成与对照组相比无显著差别。染毒后6个月肺羟脯氨酸含量显著增加,肺间质成纤维细胞增生和胶原纤维沉积,表明肺间质有轻度纤维组织增生。根据本实验结果采用Sanders公式进行初步估计,如城市SP不超过现有国家标准,人在10年中所吸入的SP总量尚低于可能引起肺纤维组织增生的剂量。更多还原

【Abstract】 Suspended partieulates (SP) is one of the most important air pollutants in urban areas. Syrian hamsters were instilled intratraoheally with Shanghai SP (15 mg/kg). 3 and 6 months after exposure,, these hamsters were sacrificed, and their lungs lavagod. The biochemical components and macrophage numbers in the broncho-alveolar lavage fluid showed no significant difference from the control group. However, lung hydroxyproline increased significantly six months after exposure. Pathological examination showed slight libroblastic proliferation in the lungs. Sanders’ equation was usod in the evaluation of the effect of SP on health. If the concentration of SP is kept below the maximal allowance levels (0.15mg/m3), the total amount of SP inhaled in ten years will not cause libroblastic proliferation.更多还原