【摘要】 用显微图象测量仪微机测量100例生育异常男性和60例正常男性的Yqh/16p相对长度比率。结果:生育异常组和正常组Yqh/16p五个等级类型及出现频率均较接近;众数均为3级;两组Yqh~+(≥4级)频率无差异。对自发流产、死胎死产、自发流产伴死胎死产各组分别与正常组Yqh~+频率比较,均无显著性差异(p>0.05)或正相关;对自发流产或死胎死产发生次数不等个体的Yqh~+频率比较,均无正相关。提示:大Y染色体(Yqh~+)与自发流产或死胎死产等常见生育异常之间无明显相关。更多还原

【Abstract】 C-band heteromorphism was studied quantitatively in 100 married couples with histories of 2 or more spontaneous abortions, and/or fetal deaths, and also in a control group of 60 married couples with normal babies. In this population, the 160 wives all had a normal female karyotype without any heteromorphism. The relative lengths of Yqh/16p ratios were measured by a computerized micro-videomat system. The frequencies of Yqh/16p from the 1st to 5th levels in 100 males with abnormal fertility histories were similar to those in 60 males with normal fertility; the mode of Yqh/16p were the 3rd levels in both groups. The Yqh+ ferquencies of both groups set in the 4th and 5th levels were not significantly different (18%, 18.3%), and also there was no significant difference between each groups--spontaneous abortion, intrauterine fetal death, spontaneous abortion plus intrauterine fetal death, and normal fertility, there was no positive correlation between the incidence and frequency of Yqh+ and the occurrence of fertility abnormals in any one individual. These data indicate that the large Y chromosome (Yqh+)is not a direct cause of spontaneous abortion and/or fetal deaths.更多还原