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丝棉木的三萜成分研究Ⅰ

STUDIES ON THE TRITERPENOID CONSTITUENTS IN EUONYMUS BUNGEANUS I

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【作者】 周军良; 潘德济; 李珠莲;

【Author】 ZHOU JUNlIANG, PAN DEJI, LI ZHULIAN(Department of Chemistry of Natural Drugs, Faculty of Pharmacy, Shanghai Medical University, Shanghai)

【机构】 上海医科大学药学系天然药物化学教研室; 上海医科大学药学系天然药物化学教研室 研究生; 导师; 导师;

【摘要】 从药用植物丝棉木Euonymus bungeanus,Maxim的茎木部分离得八种三萜(Ⅰ~Ⅷ)。经波谱和其他理化性质分析,确定Ⅰ为moronic acid,Ⅱ为雷公藤内酯乙(wilforlideB),Ⅲ为雷公藤内酯甲(wilforlide A),Ⅳ为齐墩果酸(oleanolic acid)和Ⅷ为3β,22α-二羟基-△12-齐墩果烯-29-羧酸。上述成分均为首次从丝棉木中分得。此外还得到没食子酸。

【Abstract】 From the woody part of the stem of Euonymus bungeanus, Maxim, eight crystalline triterpenoid compounds have been isolated. Based on the physicochemical constants, especi lly the spectral data, the structures of these compounds were identified. I, mp 224-226℃, C30H46O3, is moronic acid. II, C30H44O3, is wilforlide B. III, mp 330-332℃, C30H46O3, is wilforlide A. IV, mp 302-310℃, C30H48O3, is oleanolic acid. VIII, mp 315-322℃, C30H48O4, is 3β, 22α-dihydroxy-Δ12-oleanen-29-cic acid. They have been further confirmed by comparing or correlation with authentic samples. Besides the triterpenoid constituent, gallic acid was isolated from the soluble portion of ethyl acetate.

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