【摘要】 将胆碱类药物毒扁豆碱和东莨菪碱微量注入隔核,观察其对电针镇痛的影响。家兔电针后,单侧隔核注入毒扁豆碱,可加强电针的镇痛效应。单侧隔核注入东莨菪碱可阻断电针的镇痛效应。结果提示:隔核内胆碱能系统可能参与电针镇痛。更多还原

【Abstract】 This is a report of investigations on the role of the cholinergic system of rabbit septal nuclei in electro-acupuncture analgesia. Analgesic effects were observed under the following conditions: Unilateral electro-acupuncture of "Hegu" and "Waiguan" at a frequency of 4 Hz and a voltage causing slight twitching of the fore limbs, while the animals were maintained in a quiet state. The pain threshold was measured by the potassium ion dolorimeter.Analgesic effects of electro-acupuncture were marked] y enhanced after micro-injections of physostigmine (4μg) into the septal nuclei unilaterally. Maximal effects were obtained after 18-24min, in 10 rabbits.Another 10 trials in 7 rabbits receiving unilateral septal nuclear injections of 10μg of scopolamine, showed decreases in analgesic effects 9-15min after injection.Results suggest the oholinergic system of the septal nuclei to be concerned with analgesia and electro-acupuncture analgesia.更多还原