【摘要】 报道包甲素全身及局部用药毒性研究。包甲素苯甲酸盐小鼠腹腔给药的急性LD₅₀为8.85±1.2mg/kg。中毒症状系强烈的拟胆碱作用所致。急性中毒组织病理检查小鼠及猴大致相同,主要是内脏器官淤血。亚急性给药试验提示有一定的积蓄性。慢性滴眼试验,兔内眼及外眼部未见任何明显损害。正常志愿者滴眼试验和匹罗卡品类似,虽有短暂球结膜血管扩张。但毫无不适感觉。解毒试验证明抗胆碱药阿托品是一个高度特异性解毒剂,为临床用药提供了安全保证。更多还原

【Abstract】 Baojiasu is an effective drug used in the treatment of glaucoma. Because of its strong parasympathomimetic action, the study on its toxicity is of great importance. According to Karber’s method the acute LD 50 of Baojiasu benzoate injected intraperitoneally in mice is 8.85±1.2 mg/kg. Pathological examination of the mice and that of a monkey died from acute intoxication show mainly blood stasis in visceral organs. Subacute administration of Baojiasu indicates that there is possibly a cumulative action of the drug in mice.When applied locally to rabbit’s eyes 3 times daily for 3 months, Baojiasu was proved no harmful effect on rabbit eyes. No significant changes in external or internal strutures of the eyeball are found. Baojiasu eyedrop applied to normal volunteers can induce temporary dilatation of conjunctival vessels but causes no discomfort. Antidotal study revealed that the toxic effects of Baojiasu can be specifically antagonized by atropine, therefore one can feel secure about the use of the drug.更多还原