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躯体局灶性刺激对脑脊液中单胺类物质含量的影响

Effect of Local Somatic Stimulation on Monoamines Content in Cerebrospinal Fluid

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【摘要】 不同强度电针刺激家免相当于“环跳穴”部位,用萤光法测定其脑脊液中5-羟色胺(5-HT),5-羟吲哚醋酸(5-HIAA),多巴胺(DA),去甲肾上腺素(NE)等单胺类物质含量的变化,发现强刺激组四种或份均升高,但升高幅度不同。弱刺激组及弱加强刺激组5-HT 和5-HIAA 上升而 DA 和 NE 则降低。这些变化均有统计意义。此实验结果提示三种不同方式的刺激所引起的神经过程不尽相同,均能引起脑内单胺类物质变化,说明这些物质与电纤刺激和疼痛刺激有一定的相关性,但这种相关变化的机制尚待进一步探讨。

【Abstract】 Electro-acupuncture stimulation of different intensity was bilaterallyapplied to rabbits’ “Huantiao”points.The changes in concentrationof 5-hydroxytryptamine (5-HT),5-hydroxyindole acetic acid (5-HIAA),dopamine (DA) and norepinephrine (NE) were measured by means offluorometry.Concentrations of the four monoamines were found toincrease significantly in varying extent under strong stimulation;therewere an obvious rising of 5-HT and 5-HIAA but an obvious decreasein DA and NE concentration in case of weak stimulation and weak plusstrong stimulation.All these changes were statistieally very significantThe results indicate that the neural processes caused by the threedifferent means may not be completely the same and alterations inmonoamine concentrations can be evoked by these stimulations.Thissuggests that there is certain correlation between these chemicals andelectro-acupuncturing as well as noxious stimulation.Further study ofthe correlation mechanism is needed.

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