【摘要】 在高胆固醇血症动物模型上,通过观察血小板聚集率,血小板内cAMP和cGMP等指标的动态变化,研究了大蒜素抗血小板聚集的作用。结果表明大蒜素具有明显抑制高胆固醇血症引起的血小板聚集作用,这种作用是通过提高血小板内cAMP这一重要环节实现的,对cGMP含量无明显影响。更多还原

【Abstract】 32 New Zealand rabbits weighing 1.5～2.5kg were divided intothree groups:group Ⅰ( the control group, n=10 ); group Ⅱ (n=11 ) and groupⅢ ( n=11 ). They were all fed with common-stock diet.Except for the controlgroup, group Ⅱ received cholesterol ( 0.5g/kg body weight ) daily, while groupⅢ was fed with 0.5/kg of cholesterol plus the Allitridi (diallyl trisulfide, 20mg/kg ). Blood cholesterol, platelet aggregation, platelet cAMP and cGMP in-dex were determinined by the usual techniques at fixed time. The observationwas finished at the end of 15th week. The rise in serum cholesterol was signi-ficantly reduced by Allitridi during the 15-week period of study. Platelelet agg-regation in group Ⅱ was significantly higher than that in group Ⅰ(p<O.05),while in group Ⅲ it was close to that the control group but significantly lowerthan in group Ⅱ ( P<0.01 ). There was a negative correlation between plateletcAMP and platelet aggregation ( r=-0.42, p<0.05 ). Platelt cAMP in groupⅡ was little higher than in the control group ( p>0.05 ), while significantlyhigher than in group Ⅱ ( p<0.001 ). There was no difference of platelet cGMPbetween group Ⅱ and group Ⅲ. It is suggested that Allitridi has a powerfulanti-aggregating effect on platelet in hypercholesterolemia rabbits and its inhi-bition of platelet aggregation is mediated by an increase of platelet cAMP.更多还原