【摘要】 9例瘤型麻风曾用DDS治疗15～30年临床治愈者,6例在原皮损内的真皮血营周围有数目不等的泡沫细胞,抗酸染色阴性,苏丹Ⅳ染色呈猩红色。泡沫细胞内琥珀酸脱氢酶无活性或活性显著降低。直接免疫荧光检查,泡沫细胞中未发现有IgG、IgA、IgM及C₃沉积,2例在基底细胞膜带有IgM沉积,1例毛细血管壁有IgG沉积。透射电镜观察发现泡沫细胞中有大小不一的空泡,大空泡中又有大小不一的小空泡,均有单位膜包绕,泡壁部分破裂,彼此连成泡沫状;含有脂滴,细胞器很少,未见麻风菌。成纤维细胞粗面内质网发达,高度扩张呈泡状,类似泡沫结构。作者认为这种泡沫细胞新陈代谢能力很低,因是衰退性细胞,本身无力消除其泡沫结构,故长期不能消退;其次是它周围很少有巨噬细胞,所以也不能从外部清除这些细胞。更多还原

【Abstract】 The pathologic changes of foam cells in regressive skin lesions of 9 arrested lepromatous leprosy patients, who have been treated by DDS for 15～30 years, are reported. The cells varied in number around the Small dermal vessels in six of nine cases, but no bacilli were found in them. The cells were stained red by Sudan Ⅳ.The a ctivity of succinic dehydrogenase disappeared or markedly decreased in the cells. Direct immunofluorescent examination showed that there was no deposition of IgG, IgA, IgM and G₃ in the cells. IgM could be determined at the dermo—epidermal junctons of two cases and in capillary walls of one case. Electron-microscopic study of the cells showed there were vacuoles of varing sizes within their cytoplasms, from which Large vacuoles contained many small vacuoles of varying sizes, and each of them was surrounded by a unit membrane, Some vacuole walls were discontinuous. The foam cell contained a nomerous of fatty drops and a few cell organs but no M. leprae. The rough endoplastic reticula were well developed and markedly dilated in proliferating fibroblast cells. They looked like foamy structure. It is concluded that these foam cells possess much lower metabolism and may persist for a long time because they are degenerated cells which are not able to clean away the foamy structure. On the other hand, a few macrophages around the foam cells also could not dispose of away them.更多还原