【摘要】 本实验通过外源性 cAMP 和茶碱对人胃腺癌细胞系 SGC-7901的连续作用,观察到外源性 cAMP 和茶碱对该细胞株的增殖,具有明显的抑制作用。在透射电镜和扫描电镜下,均可见到细胞表面较光滑,微绒毛减少或消失。同时见到细胞膜表面上的 Na~+—K~+—ATP 酶活性受到抑制。本文讨论了外源性 cAMP 对人胃腺癌 SGC-7901细胞系增殖的抑制作用,以及膜表面微绒毛和Na~+—K~+—ATP 酶活性变化的关系。更多还原

【Abstract】 To cell culture medium of human stomach glandular carcinoma,cell line SGC-7901, 1mmol/L of cAMP and 1 mmol/L theophylline was added,The growth rates of the cultured cell was obviously depressed,SEM observation showed the regression of microvilli on the cell surface,and at the same time,TEM observation showed a mark reduction of Na~+-K~+ -ATPase activities. Exogenic cAMP and theophylline would elevate the intracellular content of cAMP,and the regression of microvilli and reduction of ATPase activity may indicate the reversion of the cancer cell.更多还原