【摘要】 本研究应用G显带技术对34对自然流产夫妇进行了细胞遗传学研究,发现4例染色体异常,发生率为5.8%,染色体异常以平衡易位为主。其中46,XX,t(12;18)和45,XX,t(13;22)一易位核型,国内尚未见报道。此外还发现2例9号染色体臂间倒位。更多还原

【Abstract】 Chromosomal banding was studied on thirty-four couples with spontaneous abortions, among which four abnormal karyotypes were found. The frequency of chromosomal abnormality among the couples with spontaneous abortions was 5.88%, and most of the abnormal karyotypes was balanced translocation. It is suggested that spontaneous abortion is the cytogenetic effect of abnormal chromosome carriers. In addition, according to the type of abnormal karyotype, the carriers may give birth to children with congenital abnormalities. Therefore, they should be monitored by prenatal diagnosis. Two pericentric inversions of chromesome 9 were discovered and its effect of cytogeneties was discussed.更多还原