【摘要】 作者用铬剂对实验性家兔高脂血症和动脉粥样硬化的影响进行了观察。通过测定血脂和对主动脉弓粥样硬化斑块形成的观察表明:造型给药组较造型对照组胆固醇低43.9％、甘油三脂低72.7％、主动脉弓粥样硬化斑块的形成率低42.8％。急性和亚急性毒性试验表明毒性较小。更多还原

【Abstract】 Experimental hyperlipidemia and ather-osclerosis were produced by feeding rab-bits with high-cholesterol-high-fat diet andthe effects of chromium preparation wereobserved. The results showed that purified chro-mium prepatation caused a docrease in chol-esterol,triglyceride and atheroscleroticplaques in the aortic arch,as 43.9%;72.7% and 42.8% respectively, and an in-crease in the content of HDL cholesterolin total serum lipids.Acute toxicity: LD₅₀in mice Ⅳ purified,rough, and extractedchromium preparations were 1844.0±147.7,780.0±76.8,711.5±86. 2mg/kg （P=0.95）respectivelty.Subacute toxicity:After intakeof the purified and extracted chromiumpreparations 10mg/kg QD×30d and 10mg/kgQD×45d PO in rabbits,liver function,kidney function showed no significantchanges. The preparation may be used clinically forthe prevention and treatment of coronaryheart disease.更多还原