【摘要】 采用手术方法造成家兔慢性充血性有心衰竭,发现心衰兔心房提取物的利钠利尿活性明显降低(与对照相比,P<0.01)。电镜观察发现,心衰兔心房肌细胞含心钠素的特殊颗粒数显减少。生物学活性检测与形态学观察结果一致。在家兔实验性心力衰竭时,心房肌内心钠素的减少可能系大量心钠素排入血液的结果。更多还原

【Abstract】 The natriuretic and diuretic effectsof atrium extracts of rabbits with con-gestive heart failure were found to begreatly decreasing as compared with con-trols (P<0.01), and observation fromelectron microscope indicated that thenumber of atrial specific granules,whichcontain cardionatrin,in congestive heartfailure rabbits also decreased as comparedwith that in normal rabbits.Both resultsanggest that in congestive heart failurethere is a decrease of cardionatrin inatrial tissue,and this may be due toits greatly compensative excretion intocirculation.The present study also introducesa conventent method for producing chroniccongestive heart failure.By use of aconstricting operation on pulmonary arteryto produce pulmonary hypertention,therabbits develop right-sided congestive heartfailure within several days.更多还原