【摘要】 采用615近交系小鼠吸入纯氯丁二烯,发现所用的最低浓度1.48mg/m~3即可导致多染红细胞微核计数显著高于对照组,且计数随浓度升高而增高,有明确的剂量反应关系。更多还原

【Abstract】 This paper presents GC pure (99.9%)chloroprene at concentrations of 1.48, 66.55,464.27, and 762.98 mg/m~3,inhalated for 2hours in soccessive 2 days by 615 inbredmice.Sin hours after the second inhala-tion, micronucleus count of bone marrowpolychromatic erythrocytes was made.Themicronuclens count in the 1.48 mg/m~3group reached 8.3‰,which was significant-ly higher than that in the control group(3.8‰).Furthermore,the result showed thatthe higher the exposure concentration,the higher the micronuclous count;thereexisted a prominent doseeffect relation-ship.Thus,the results suggest that thereis necessity to reset the present hygienestandard of chloroprene in the workroomair (2 mg/m~3).更多还原