【摘要】 用较大剂量MNNG多次灌胃LACA小鼠,分阶段处死,肿瘤的最高发生率可达100％(5/5),良瘤与癌均为82％(9/11)。缩短了前胃、腺胃及小肠的诱癌时间。探讨了各部位肿瘤发生率不同的原因。更多还原

【Abstract】 In order to shorten the inductive periodof tumors ninety LACA mice, as an ex-perimental group, were intubated by MNNG(625-1250μg/0.5ml)repeatedly with a totalamount of 6.88-30.00 mp in 4-37 weeks(29-259 days). Fifty-two LACA micewere taken as blank controls. Animalswere s?crificed in nine phases. The results of the experimental groupshowed that the highest incidence of be-nign tumor as well as cancer in all phaseswas 82%(9/10), and the highest incidenceof tumors in all phases might approach100%(5/5); the incidence of papilloma inthe fore-stomach was 66% (59/90); the squa-mous cell carcinoma in the fore-stomach31%(28/90); adenocarcinoma of glandularstomach2%(2/90); and adenocarcinoma ofthe small intestine 10%(9/90), of whichadenocarcinoma of the jejunum accountedfor 4%(4/90), and adenocarcinoma of thelower part of the duodenum 6%(5/90), andtwo were associated additionally with theupper part and lower part duodenal aden-ocarcinoma. The time of the first tumor discoveredin the gastrointestinal tract in LACA micethe amount of MNNG given were asfollow:papilloma of the fore-stomachin the 4th week (MNNG 6.88mp); thesquamous cell carcinoma of the fore-stomch in the 17th week (MNNG23.13 mg);adenocarcinoma of glandular stomach inthe 25th week(MNNG 23.75 mg); jejunaladenocarcinoma in the 17th week (MNNG23.13mg); and duodenal adenocarcinoma inthe 21st week(MNNG 23.50mg). Briefly discussed were the causes ofthe difference in the incidences among thecancers, the precancerous lesions and theproliferative changes in the fore-stomach,glandular stomach and proximal smallintestine in LACA mice after intubationwith MNNG. No cancers or precancerous lesions werefound except one mouse in the controlgroup, which had chronic lymphocyticleukemia.更多还原