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胆道显象剂99mTc-PI的制备及临床应用

PREPARATION OF 99mTc-PI AS A CHOLESCINTIGRAPHIC AGENT AND ITS CLINICAL APPLICATIONS

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【作者】 管昌田; 邓侯富; 梁正路; 莫廷树; 刘中林; 杨文宏;

【Author】 Guan Changtian;Deng Houfu;Liang Zhenglu;Mo Tingshu;Liu Zhonglin;Yang Wenhong Department of Nuclear Medicine Chengdu 515 Post

【机构】 华西医科大学核医学教研室; 华西医科大学核医学教研室 成都市515信箱; 成都市515信箱;

【摘要】 本文报道胆道显象剂99mTC-PI制备的改良方法。Sn-PI药盒在 4℃冰箱中保存有效期达 7月以上。99mTC-PI的标记率为95.2~98.9%。室温下放置 6小时保持稳定。本文分析了41例?常人99mTC-PI胆道显象的特点,并用其进行黄疸的鉴别诊断、急性胆囊炎的诊断和肠胃反流测定等共45例,均获得满意结果。

【Abstract】 A modified method of preparation of99mTc-PI as a cholescintigraphic agent isreported. The effective period of Sn-PIkit reagent was more than 7 months at4℃. The labeling efficiencies for labeling ofPI with 99mTc were as high as 95.2-98.9%.99mTc-PI was stable at room temperaturefor more than 6 hours. No side-effectswere observed, whether in the rabbitsgiven 67 times the proposed human doseor in the patients studied. 99mTc-pI cholescintigraphic studies in 41normal human subjects are also presented.Using 99mTc-PI cholescintigraphy, we madea diagnosis of acute cholecystitis in 3cases, differential diagnosis of jaundicein 29 cases and an evaluation on 13 posto-perative patients with an excellent result.

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