【摘要】 黄腐酸钠12.5mg/kg,于抗原攻击前24.3.1小时腹腔注射三次,对BPO—HSA致敏豚鼠过敏性休克有一定预防作用,实验组两次休克的平均死亡率分别为60%和33%,而对照组两次休克的死亡率分别为100%和88%,二者比较实验组休克死亡率明显降低,而且实验组两次休克平均死亡时间亦有所延长。本品83.3～166.6μg/ml加入浴器后10～15分钟,体外对致敏豚鼠离体肠管由抗原攻击引起的紧张度升高和蠕动加强明显减弱,结果表明对抗原攻击引起的介质释放有抑制作用,且随时间的延长而作用加强,观察4小时仍有明显作用。此可能与预防青霉素过敏休克的作用有关。更多还原

【Abstract】 Intraperitoneal injection of sodium fulvate(SF) into guinea-pig at the dosage of 12.5mg/kg three times,i, e, 1,3 and 24 hours before the antigen challenge, had definite prophylactic effect on a naphylgctic shock of Sensitized guinea-pig with BPO-HSA. In two experiments,the mortality of shock in the experimental group was 60% and 33%,whereas the mortality in the control group was 100% and 88%. The mortality of shock in the experimental group decreased more markedly than that in the control group.10～15 minutes after adding SF into bath at dosage of 83.3～166.6μg/ml,the tension and peristalsis of isolated and sensitized intestine of guinea-pig induced by antigen challenge in vitro were weakened markedly. It was shown that SF had a inhibifory effect on the release fo mediator of sensitized intestine. It may be related to the prophylactic effect on the anaphylactic shock of penicillin.更多还原