【摘要】 用林县粮食中分离的串珠镰刀菌和半裸镰刀菌分别发霉食物,用Wistar大鼠进行诱癌实验。实验结果:1.串珠镰刀菌组,动物喂饲霉食247～956天、30只动物中发现乳腺癌肉瘤1例,腹腔和纵隔网织细胞型淋巴肉癌3例,结肠乳头状癌1例,肿瘤总发生率为16.7％(5/30)。食管上皮增生发生率6.7％(2/30),前胃上皮为3.3％(1/30);2.半裸镰刀菌组,动物喂饲霉食65～648天、20只动物中发现腹腔网织细胞型淋巴肉瘤、膀胱乳头状瘤各1例,肿瘤总发生率为10％(2/20)。前胃上皮底层细胞增生2例,其中1例并有脐样病灶形成;3.对照组,动物喂饲未经发霉处理的正常饲料157～844天,32只动物中未发现任何肿瘤。两个实验组的大鼠肺脓肿和肺部慢性肉芽肿的展生率均高于对照组,结果提示这两种霉菌对肺脏亦有致病性。更多还原

【Abstract】 In this paper, we report an experimentaly induced cancer in rats with Fusarium moniliforme and F semitectum isolated from the corn in Linxian County. The results show: 1. The F. moniliforme group. 30 animals were fed with F. moniliforme mould food for 247～956 days. In this group, one carcinoma-sarcoma of breast, three reticulo-lymphosarcoma in abdominal cavity and mediastinum, and one papillocarcinoma in rectum were found. The incidence rate of all tumors was 16.7％(5/30). The incidence of epithelial hyperplasia of esophagus was 6.7％(2/30), and 3.3％ for forestomach; 2. The F. semitectum group. 20 animals were fed with F. semitectum mould food for 65～648 days. In the group, one reticulo-lymphosarcoma in abdominal cavity, and one papilloma in bladder were noticed. The incidence of tumors was 1％ (2/20). There were 2 cases showing basal cell hyperplasia of epithelium in forestomuch, in one of which umbilicular-like lesion was found; 3. The control group. 32 animals were fed with normal food for 157～844 days and no tumor was found in them. In group 1 and 2, the incidences of abscess and chronic granuloma of lung were higher than that in the control group. The results suggest that these two strains of fungi show pathogenecity for the lung更多还原