【摘要】 实验用离体兔主动脉条和回肠进行。实验证明阿托品可使去甲肾上腺素(NA)的量效曲线平行右移。在所用阿托品的浓度下,并不明显降低NA的最大收缩反应。常用的阿托品类药物多有类似的抗去甲肾上腺素作用,其强度顺序为:阿托品,山莨菪碱、东莨菪碱;而樟柳碱基本上无抗NA作用。剂量比率试验证明,阿托品是一个作用机制与酚妥拉明相似的NA拮抗剂。交叉保护试验证明,阿托品能对苯苄胺的阻断提供明显的保护作用。在离体兔回肠的实验中证明,阿托品对α受体的抑制性效应也有选择性对抗作用。根据上述结果可以认为,阿托品类生物碱的抗肾上腺素作用很可能是竞争性的对α受体的阻断。并认为此阻断作用可能与此类药物在感染性休克和某些疾病时的治疗作用有关。更多还原

【Abstract】 Experiments were carried out on rabbit aortic strip and ileum in the organ bath. The results of experiments with aortic strip showed that the cumulative dose-response curve of noradrenaline was shifted by atropine to the right parallelly and dose-dependently, but in the dose range used (10^-5～10^-3M), atropine did not lower the maximum response of noradrenaline, and most of alkaloids used had anti-noradrenaline action. The order of potency was atropine, anisodamine and scopolamine, but anisodine had not any. The dose ratio test demonstrated that atropine was an antagonist of noradrenaline and the mechanism of this antagonism was similar to that of phentolamine. The cross protection test demonstrated that atropine could provide a significant protecting action for the blockade by phenoxybenzamine. The experiments with isolated rabbit ileum demonstrated that atropine also had a specific antagonizing action to the inhibitory effect of alpha-adrenoceptor. Therefore9 we think that atropine-like alkaloids may be competitive alpha adrenoceptor blocking agents and the blocking a ction may relate to the therapeutic action of the alkaloids in septic shock or others.更多还原