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182例鼻咽癌遗传流行病学现场配对调查

GENETIC EPIDEMIOLOGIC SURVEY OF NASOPHARYNGEAL CARCINOMA

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【作者】 肖分元吴彭年吴建民陆宗孟唐振强戴龙高飞

【Author】 Xiao Fenyuan Wu Pengnian Wu Jianmin Lu Zongmeng Tang Zhengqiang Dai Long Gao Fei Department of epidemiology, Hunan Medical College Chen-Zhou Hygiene and Anti-epidemic Station Gui-Yang Hygiene and Anti-epidemic Station Jia-Huo Hygiene and Anti-epidemic Station

【机构】 湖南医学院流行病学教研室湖南省郴州地区卫生防疫站湖南省桂阳县卫生防疫站湖南省嘉禾县卫生防疫站

【摘要】 本文调查了182例鼻咽癌病例及其对照者一、二级亲属成员的家族癌曾患情况,结果表明鼻咽癌家族聚集性十分明显,鼻咽癌病例一级亲属成员易患鼻咽癌的风险为正常人群的13.2倍。鼻咽癌的遗传方式较为符合多基因遗传,遗传度为49±6%。

【Abstract】 A pedigree study was conducted on 182 cases of nasopharyngeal carcinoma (NPC) and pair-matched controls in three counties and one city, in the south of Hunan Province from September, 1984 to January, 1985. The prevalence rates of NPC in the Ist-grade and the 2nd-grade relatives of cases and controls were 8.6‰, 5.2‰, 0.6‰ and 0 respectively. The difference between the Ist-grade relatives of cases and controls was statistically significant (X2 =10.51, P<0.005)and showed that there was an obvious familial clustering of NPC and especially, increased risk of NPC among the Ist-grade relatives of cases (relative risk=13.2, P<0.005). The hereditary mode of NPC may be coincident with multigenic inheritance. The hereditability was 49±6%

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