【摘要】 本文调查了182例鼻咽癌病例及其对照者一、二级亲属成员的家族癌曾患情况,结果表明鼻咽癌家族聚集性十分明显,鼻咽癌病例一级亲属成员易患鼻咽癌的风险为正常人群的13.2倍。鼻咽癌的遗传方式较为符合多基因遗传,遗传度为49±6％。更多还原

【Abstract】 A pedigree study was conducted on 182 cases of nasopharyngeal carcinoma (NPC) and pair-matched controls in three counties and one city, in the south of Hunan Province from September, 1984 to January, 1985. The prevalence rates of NPC in the Ist-grade and the 2nd-grade relatives of cases and controls were 8.6‰, 5.2‰, 0.6‰ and 0 respectively. The difference between the Ist-grade relatives of cases and controls was statistically significant (X2 =10.51, P<0.005)and showed that there was an obvious familial clustering of NPC and especially, increased risk of NPC among the Ist-grade relatives of cases (relative risk=13.2, P<0.005). The hereditary mode of NPC may be coincident with multigenic inheritance. The hereditability was 49±6%更多还原