节点文献
β-桉烯和其衍生物的合成及其抗生育活性
The synthesis and antifertility effect of β-selinene and its derivatives
【摘要】 本文叙述了倍半萜类化合物——β-桉烯、衍生物Neointermedeol以及1,2,3,4,7,8-六氢-5,8-二甲基-3-异丙烯基萘的合成。初步药理筛选结果表明,这三个化合物均具有一定的抗生育活性。化合物还未见报道,它的化学结构在本文得到证实。
【Abstract】 The synthesis of sesquiterpenes—β-selinene (8), neointermedeol (9), and 1, 2, 3, 4, 7, 8-hexahydro-5, 8-dimethyl-3-isopropenyl naphthalene (11)—is described. These three compounds were endowed with antifertility effect to a certain extent indicated by preliminary pharmacological test.The compound (11) has not been reported in the literature, its chemical structure was identified by the spectra data.
【关键词】 桉叶烷;
避孕药;
倍半萜;
药物化学;
有机合成;
【Key words】 eudesmane; controceptive; sesquiterpene; medicinal chemistry; organic synthesis;
【Key words】 eudesmane; controceptive; sesquiterpene; medicinal chemistry; organic synthesis;
【基金】 中国科学院科学基金资助的课题
- 【文献出处】 华东化工学院学报 , 编辑部邮箱 ,1986年04期
- 【被引频次】1
- 【下载频次】41