【摘要】 对姜黄烯类倍半萜进行了研究。全合成得到(±)α-姜黄烯、(±)β-姜黄烯,脱氢-α-姜黄烯三个倍半萜类化合物。经药理初筛,表明都具有一定的抗早孕生物活性,还探索了倍半萜姜烯的合成,由6-(4′-甲氧基-1′,4′-环己二烯)-2-甲基-2-庚烯经酸性水解得重要中间体6-(4′-羰基-1′-环己烯)-2-甲基-2-庚烯(姜烯酮)。经光谱解析,确证在所用酸性水解条件下,β,γ-碳碳双键并不随同转位。这与甾体合成中,相应的酸性水解反应不同。更多还原

【Abstract】 The synthesis of curcumene sesquiterpenes—(±) a-curcumene, (±)β-curcurnene and dehydro-a-curcumene—is described. These three curcumene analogs are endowed with antifertility effect to a certain extent indicated by preliminary pharmaeological test.The synthesis of zingiberone, the key intcrmcdiate of zingiberene, is also described. The author found that in contrast with the acid hydrolysis of β,γ-unsaturated enol ether in steroid chemistry, the enol ether group of the precursor, 6-(4′-methoxy-1′,4′-cyclo-hexdienyl)-2-methyl-2-heptene, was transformed into carbonyl group without the accompanying isomerization of β,γ-double bond under the appropriate condition of acid hydrolysis.更多还原