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杀菌剂农药敌锈钠的毒性研究
STUDY ON THE TOXXCITY OF BACTEEICIDAL PESTICIDE DI-XIU-NA
【摘要】 99%纯度的敌锈钠,以不同剂量给小鼠灌胃,其LD50>5,000mg/kg。在亚急性毒性实验中,实验动物组的白细胞总数和血清谷丙转氨酶均较对照组有明显升高。统计学有显著性差异(P<0.05)。同时还观察到各给药组小鼠肝体积增大,胞浆疏松、病变广泛;而对照组动物未见异常。此外,还对两种动物进行尿液检查和致畸胎实验,均无明显变化,实验结果表明敌锈钠属低毒性农药。
【Abstract】 The LD-50 of 99% Pure DI-XI-NA administered oraffy was found to be greater than 5000mg/kginmice. The WBC and SGPT were markedfy efevated in the animals of subacute toxicity experimental grcup ss compared with the animals of subacute toxieity experimental group as compsred with the control group(p0.05).ln experimental animals, the histological changes of liver cells were characterizeg by widespread baffoning degeneration, whereas no abnormal change hes been found in the control animals. Either in expermenyal animals or in control animals no obvious changes in urine cxsmination and terstogenic test were dctcotcd. These results indicated that the bacscrcidal pcsficidc DI-ZI-UNA is of low texicity.
- 【文献出处】 河北医学院学报 , 编辑部邮箱 ,1986年02期
- 【被引频次】3
- 【下载频次】39