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应用0、36%NaCl 磷酸盐缓冲液检出地中海贫血方法的探讨

0.36% NACI PHOSPHATE BUFFER ASSAY IN DETECTING THALASSEMIAS

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【摘要】 本文对0.36%NaCl 缓冲液渗透溶血试验筛选地中海贫血的可靠性进行研究,经不断改良及完善,在870人中用本法与经典方法进行对照检测,本试验对地贫的敏感性为91.11%,特异性为94.8%,正确性为94.6%,且简便易行,故作为地贫人群调查的过筛试验是很有价值的。

【Abstract】 Thalassemias are detected by 0.36% NaCl phosphate buffer assay with evaluation.When compared with results obtained from 0.36% NaCl phosphate buffer assay and classic method,no significant differences were found.This assay was applied for 870 normal subjects and variant disorders,the results shown that 0.36% phosphate NaC1 buffer assay for detecting thalassemias were be useful,its sensitivity was 91.1%,specificity 94.80% and accuracy rate 94.60%.0.36%NaCl phosphate buffer assay is easy to perform,and can be used for screening of thalassemias in mass population survey.

【关键词】 地中海贫血; 渗透脆性; 缓冲剂;
【Key words】 Thalassemia; Osmotic fragity; Buffers;
  • 【文献出处】 贵阳医学院学报 ,Journl of Guiyang Medical College , 编辑部邮箱 ,1986年04期
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