【摘要】 利用我室自制的电脑控制肌格监测装置,临床定量测量海轮碱Ⅱ0.4mg/kg单次静脉推注后的肌松效能。实验结果表明:海轮碱Ⅱ达到峰值所需时间为15.5±2.2min（X±SD）最大肌松效应时的T₁%、T4/T1、F%分别是40.5±11.7、20.0土5.5、19.8土7.3;T4/T1恢复到70所需时间为106.0±22.1min。实验还得知:海轮碱Ⅱ对呼吸肌的影响与肌松效能不一致。更多还原

【Abstract】 The dynamic process of muscle relaxant property of D1ME-THYL 1-CURINE DIMETHOCHLORIDE (L-DCD) was measured in patients (40cases, 0. 4mg/kg i. v bolus) using a microcomputer-assisted system for monitoringmuscle relaxation (designed and built in our lab. ). The use of "train of four" sti-mulator with an adequate transducer, the incorporation of a microcomputer-as-sisted monitoring device make the muscle relaxation measurement objective andmore informative. The data (T1, T4/T1, F, etc. ) thus provided are immediate aswell as more accurate. Results showed that the peak relaxation time was 15. 5±2. 2 min (X±SD),the relative muscle force of T1%, T4/T1, F% (compared with the force beforedrug administration in terms of percentage) at the maximal relaxation was 40. 5±11.7, 20.0±5.5, 19.8±7.3; the time from peak relaxation value of T4/T1 to 70of recovery was 106.0±22. 1 min. Our study revealed that respiration paralysis did not coincide with peak mus-cle relaxation.更多还原