【摘要】 <正> 支气管激发试验可敏感地测定支气管的反应性。它在国外被广泛用于支气管哮喘鉴别诊断、发病机理研究、流行病学调查及其病情、疗效的观察等。但目前国内对组胺支气管激发试验的报道甚少。为了探讨本地区哮喘病人对此试验所表现的特征,我们对61例哮喘患者进行了测定,并与正常人和轻度慢性支气管更多还原

【Abstract】 Histamine bronchial provocation test was performed in 61 patients with various severity of asthma, 18 were mild chronic bronchitis and 20 were normal nonsmokers. It was using the cumulative twofold-dose increment method. The result showed that PD20-FEV1(Hista- mine dose causing a 20% fall in FEV1) and TD(Histamine dose at which a decrease in FEV1 exceeds 2 SD from pre-histamine FEV1) in various asthma group were significantly lower than that in chronic bronchitis group and nornal group(P<0.01), while R(the slop of dose-response curve) was remarkably higher in asthmatics(P<0.01). We suggest that in patient with episodic dyspnea or cough, the diagnosis of bronchial asthma be made if PD 20-FEV1 were below 1.1mg(3.58umol), TD and R are useful indices in identifying asthma.更多还原