【摘要】 为了寻找有效的辐射损伤防护药,改进及新合成芥子酸及胺盐衍生物,用ESR波谱研究电子从靶分子脱氧胸腺嘧啶核苷酸(dTMP)向芥子酸长程转移的保护机理。经辐照小鼠的试验表明:辐照损伤引起的外周血小板下降症可以被芥子酸胺盐衍生物保护。并报道了芥子酸类衍生物的红外及核磁共振光谱。更多还原

【Abstract】 In order to find more effective radioprotector, an improved newmethod to synthesis sinapic acid and its amine salt derivatives has been reported, andthe study of ESR spectra from sinapic acid-dTMP with molar ratio 1:10 irradiatedand recorded at 77 K has confirmed the long range electron transfer from thymine ofdTMP to sinapic acid:also, the radioprotective effect of sinapic acid amine salt derivatives on irradiated mice(500 rad.) has been shown in increasing peripheral platelet count with significance ofstatistics. The I. R and NMR spectra of sinapic acid derivatives also have been repor-ted.更多还原