【摘要】 本文报导四组实验大鼠(正常对照组,矽肺组、磷酸喹哌组、氮氧喹哌组)的血浆及肺冲洗中脂质过氧化物(Lipidperoxide简称LPO)的测定,结果发现,矽肺组血浆及肺冲洗液中LPO的光密度与正常对照组比较,差异非常显著,(P<0.01),提示矽肺的发生可能与游离基的生成有关。磷酸喹哌组和氮氧喹哌组血浆及肺冲洗液中LPO的光密度与矽肺组比较,差异非常显著P<0.01,提示作为抗矽肺药物磷酸喹哌及氮氧喹哌有降低LPO的作用。本实验结果为矽肺发病过程及治疗方面提供参考。更多还原

【Abstract】 We detected lipid peroxide in plasma and fluid from lavaged lungs samples from four groups of experimental rats. The results of laboratory observation showed that the silicotie group were significantly higher than the control group (p<0. 01), and the other two groups used antisilicotie drugs were significa- ntly lower than in silicotic group (p<0. 01). This suggests that the formation of silicosis may be related to the free radical and the lipid peroxide levels may be decreased by the two antisilieotie drugs. The present paper provided scientifc basis for further study of the mechan -ism of silicosis and new preventive measures.更多还原