【摘要】 本文记述了用鼠疫强毒菌512号菌株感染鼠疫疫区旱獭的试验,初次感染时。10亿个菌组的旱獭全部死亡。感染一年后,对存活的旱獭再次攻击则可耐受700亿菌,其耐受性明显增加。旱獭感染后的嗜中性白细胞数量高于感染前,10天后恢复正常。旱獭初次感染鼠疫后,5天内不产生抗体,10天后阳性率为100％,最高滴度为1:1280。再次感染5天后的阳性率达100％,最高滴度为1:40960,可持续一年之久(1:40)。初次和再次感染之旱獭血清,其MPI分别为<10和<5,E-玫瑰花结合力和淋巴细胞转化率显著高于感染后(p<0.05)。 本研究有助于青海喜马拉雅旱獭动物流行病的调查。更多还原

【Abstract】 Death rate of M himalayana following infection was related to infective doses, all of animals which had first been infected with 109 plague bacilli (virulent strain 512) succumbed to plague, some of survivors infected with <108 Y. pestis could tolerate the challenge to 7×l010 virulent plague bacilli 1 year later after infec tion The total counts of leucocytes and neutrophils after infection were higher than those before infection and declined to normal 10 days later. IHA antibody was not detected in any animals within five days after first exposure to plague, the positive rate was 100% after 10 days, the highest titre being 1:1280; however, IHA antibody appeared 5 days later in all animals which were reinfected, the highest titre being 1:40960, and the antibody persisted for a year (titre of 1:40). MPIs of sera of infected and reinfected animals were <10 and <5 respectively. Both the E-rosette test and lymphocyte transformation rates were higher than those belore infection更多还原