【摘要】 本文报道了克山病病人的免疫功能变化及用克山病病区粮喂养大白鼠的免疫功能改变,研究结果表明,克山病病区人群的免疫功能一般偏低,慢性和潜在型克山病患者免疫球蛋白水平增高,尤以IgA和IgM为显著。克山病患者的抗核抗体阳性率增高,循环免疫复合物水平也有增高的趋势,患者心肌组织中有IgG的沉积,表明克山病患者有免疫学改变,并具有自身免疫反应特点;用克山病病区粮喂养大白鼠,可使其免疫功能受到一定影响,主要表现为T细胞数的减少及T细胞功能的降低,病区粮加硒后对其影响不明显,提示病区粮因素所致的机体免疫功能改变在克山病的发病过程中可能有一定影响,而硒可能只是免疫学改变的一个因素而已。更多还原

【Abstract】 Observations on changes of immunologic functions of patients with Keshan disease and of rats fed on cereals grown in Keshan disease area showed that the po pulation in Keshan disease area had a tendency of a lower level of immunologic (unction, that patients with chronic or latent type of Keshan disease had elevated levels of immunoglobulins(Ig), particularly the IgA and IgM, that the level of circulating immune complex as well as the positive rate of antinuclear antibody of the patients tended to increase, that IgG deposits existed in cardiac muscular tissue, indicating that sufferers from Keshan disease experienced immunologic changes with features of autoimmune response, and that rats fed on cereals grown in Keshan di sease area had reduced number and function of T cells, with no improvement following supplementation with selenium to the cereals, suggesting that alterations of immunologic functions of the organism caused by the cereal factors of disease urea may play a part in the pathogenesis of Keshan disease and that selenium may only be one factor leading to immunologic changes.更多还原