【摘要】 BALB/C小鼠以CCI4橄榄油腹腔注射致中毒性肝坏死,部分小鼠分别给予丙酸睾酮或戍酸雌二醇皮下注射,见睾酮对雌、雄小鼠活存率无影响,但可提高秋水仙碱对雌鼠的治疗效果（秋水仙碱对雄鼠治疗效果优于雌鼠）。雌二醇则促使雄鼠全部死亡,加用秋水仙碱能使半数雄鼠活存,有显著差别（P<0.05）。单用雌二醇能使雌鼠对抗较大剂量CCI₄的毒性作用,可使雌鼠全部活存,与单用秋水仙碱治疗有显著差别（P<0.05）。更多还原

【Abstract】 Toxic hepatic necrosis (THN) was induced in BALB/C mice by CCl4 infection (i.p.) and then colchicine (orally), testosterone propionate or estradiol valerate (s.c.) were administered. The experimental results reveal that the effect of colchicine on THN was better in male mice than that in femalemice.Testosterone propionate had no effect on the survival rate of male and female mice with THN, but enhanced the therapeutic effect of colchicine on THN in female mice. All male mice with estradiol died and half of them with estradiol and colchicine survived(P<0.05). Female mice with estradiol could tolerate the toxic effect of larger dosage of CCl4 so that all animals survived.It appears that the effect of estradiol on THN in female mice is superior to that of colchicine (P<0.05).更多还原