节点文献
用Sn+2-树脂制备99m-Tc-平阳霉素
PREPARATION OF 99m-Te-PINGYANGMYCIN WITH Sn+2-RESIN
【摘要】 99m-Tc-平阳霉素是临床常用的亲肿瘤显影剂。用吸附Sn+2的阳离子交换树脂可以制得具有较好重复性的、稳定的99m-Tc-平阳霉素。标记率在90%以上。艾氏腹水实体癌小鼠分布实验表明99m-Tc-平阳霉素具有亲肿瘤作用。这种标记方法和其他方法比较,具有操作简便、可以作成药盒供临床使用等优点。
【Abstract】 99m-Tc-pingyangmycin (Bleomycin A5) has been widely used for clinical tumor ima-gingt Stannous ion adsorbed onto a cationic exchange resin shows specific characteristicsallowing the preparation of a stable 99m-Tc-pingyangmycin with good reproducibility.The labeling yeild is above 90%. The tumor-localization property of 99m-Tc-pingyangmycin was confirmed in mice inoculated with Ehrlich ascites tumor(solid form). Sn-resin labeling method has many advantages when compared with others, such as ease of performance and formulation of a Sn-resin kit system for clinical use.
【Key words】 99m-Tc-pingyangmycin; stannous; ion; resin; tumor; imaging; agent;
- 【文献出处】 重庆医药 ,Chongqing Medical Journal , 编辑部邮箱 ,1986年03期
- 【下载频次】7