【摘要】 本文对42例患者血清的苯妥英钠浓度及17例唾液浓度用放免测定法进行监测。血清DPH浓度在控制组与未控制组、控制组与药物中毒组之间均有显著差异,唾液浓度控制组比未控制组明显高。又DPH药物为非线性药理动力学特征药物,个体差异大,影响药物水平因素很多,因此药物监测指导合理用药是必要的。更多还原

【Abstract】 The measurement of DPH concentration both in serum for 42 patients and in saliva for 17 patients was performed by the use of the radioimmunoassay. There was statistically significant difference for serum DPH concentration either between seizure controlled and uncontrolled groups or between seizure controlled and dilantin intoxication groups. The saliva DPH concentration in the seizure controlled patients was higher than that in uncontrolled patients.DPH is a drug with non-linear pharmacokinetics. There are many factors affecting the level of DPH and great variations among individuals. The measurement of serum or saliva level is necessary for the valid use of the drug.更多还原