【摘要】 1981～1984年在四季青乡检测孕妇血清甲胎蛋白以筛选开放性神经管缺损畸形2,812名,随访2,798名,畸形发生率为13.58‰(38/2,798),神经管缺损畸形发生率7.50‰(21/2,798),占全部畸形的55.26%。在孕28周前检出的畸形均给以终止妊娠,使该乡的围产死亡率从28.23‰降至22.15‰。研究证明在乡一级以孕妇血清甲胎蛋白筛选开放性神经管缺损畸形对降低围产死亡率有重要意义。更多还原

【Abstract】 From May 1981 to April 1984, serum AFP screening in 2,812 cases of pregnant women for open NTDs at All Green Commune in Beijing was done. 2,798 cases were followed up. As a result, the incidence of malformations in this Commune was 13.5‰ (38/2,798) and that of NTDs was 7.5‰ (21/2,789) which represented 55.26% of the total malformations. All the malformations detected before 28 weeks of gestation were terminated. Thus, the perinatal mortality rate was reduced from 28.23‰ to 22.15‰. This study showed that serum AFP screening in pregnant women for open NTDs at Commune level is feasible and could be an important method for reducing the perinatal mortality.更多还原