【摘要】 应用荧光光度术对人胃低分化粘液腺癌细胞、人鼻咽癌上皮样细胞以及人二倍体成纤维细胞进行了HPD的摄取和存留的定量研究;并做了HPD加光照的光敏杀伤效应的比较实验。此外,对HPD的“亲水部分”和“疏水部分”的光敏杀伤效应进行了比较。HPD在人胃癌细胞及鼻咽癌细胞内的存留多于成纤维细胞。HPD的“亲水部分”的光敏杀份效应大于“疏水部分”。更多还原

【Abstract】 Human gastric low-differentiated mucous adenocarcinoma cell, human epithelial cell of nasopharyngeal carcinoma and primary cultures of children’s foreskin fibroblasts were used in studying the uptake and retention of HPD by means of fluorescence photometry and in comparing the phototoxicity treated with HPD and red light in these cells. In addition, we have compared the photosensitive effect of hydrophilic components and that of hydrophobic components of HPD. The retention of HPD in human gastric adenocarcinoma cells, and human nasopharyngeal carcinoma cells was more than that in fibroblasts The phototoxicity of the hydrophilic components of HPD (portion of tightly-bound HPD) was larger than that of the hydrophobic components (portion of loosely-bound HPD).更多还原