【摘要】 兔病毒性出血症是一种致死性急性传染病,取体温41℃但尚未死亡的病兔的肝组织,经电镜超薄切片研究,在肝细胞核内可见大量成熟的,直径约36nm的球状无膜病毒颗粒,还可看到细胞核的严重病变,细胞质内的细胞器,包括线粒体,内质网系统也发生不同程度的病变,这一类病毒在细胞核内复制和装配,这提示该病毒可能是一种DNA病毒。更多还原

【Abstract】 Viral hemorrhagic disease of rabbit is an acute and lethal epidemic disease newly found in China. The ultrastructure of liver cells from the diseas ed rabbits was investigated by electron microscopy.Concentrated mature nonmembranous isometric virons with a diameter about 36 nm were observed in the nuclei of liver cells.The cytopathic ultra-structural changes of the nuclei were extensive and serious. Meanwhile, the cytoplasmic organells, such as mitochondria, smooth and rough endo-plasmic reticulum also showed severe deformation or significant alterations. The results which demonstrated that the virions were replicated, and assembled in the nuclei at the early stage of infection implied that the pathogen of the viral hemorrhagic disease of rabbit probably is a kind of DNA virus.更多还原