【摘要】 AT—1420即甲基苯丙氨酸氮芥,它对大小鼠移植性肿瘤具有明显的抗瘤作用,疗效与消瘤芥(AT—1258)相似,而用量较小。 在大鼠急性和狗的亚急性毒性试验说明,AT—1420有明显抑制骨髓作用和胃肠道毒性,但对其他器官无明显的毒性作用。对大鼠连续用药2个月亦未见明显的积蓄性毒性。为此表明对于疗程较长且反复用药的抗肿瘤治疗是较理想的药物。更多还原

【Abstract】 AT-1420 is methylmerphalane mustard. Experiments showed that it possesses significant antitumor activity against tranplantable tumors in mice and rats. Its therapeutic effect was similar to that of Nitrocaphan (AT-1258) , but under lower dosage.In sub-acute toxicity test in the rats and dogs, the compound showed marked bone marrow suppession and gastrointestinal disturbance, however the compound showed no evidence of toxicity of most of organs in rats and dogs. It showed no evident of accumulative toxicity in rats. It was suggested that it is a promising antitumor drug.更多还原