【摘要】 本实验运用体内体外结合检测环境诱变物/致癌物方法,测试了从林县粮食中分离的互隔交链孢霉两菌株提取物261—B₂—3和C₁₂b3—2的诱变性。结果显示,两株提取物能直接诱发人外周血淋巴细胞SCE频率升高及染色体畸变,与对照组比较差差异极显著（P<0.01）。经小鼠体内代谢后,这两株提取物仍能诱发细胞SCE频率升高。说明两株提取物经小鼠体内代谢前后均具有诱变活性。本文还叙述和讨论了体内体外结合检测方法的优缺点。更多还原

【Abstract】 In this paper, the mutagenicity of 261- 82-3 and C12b3-2, the extracts of two strains of Alternaria alternate isolated from Linxian county. was detect-ed by using the in vivo -in vitro, method. The result indicated that the SCE frequencies and chromosome aberrations of human peripheral lymphocyte can be increased by there two extracts before they were metabolized in mice body. The difference was quite significant as compared with the control. After they were metabolized in mice body, these two extracts also have the ability to increase the SCE frequencies of lymphocyte. The result that the two extracts possesed the mutagenic activity either before or after metabolism in mice body. In this paper, the advantage and shortcomings of the method of in vivo-i vitro were discussed.更多还原