【摘要】 <正> 上海市1982年原发性肝癌发病率男性为39.29/10万,居男性恶性肿瘤第三位,女性为15.28/10万,居女性恶性肿瘤第四位。肝癌已成为常见恶性肿瘤之一。欧美发病率较低,一般在0～4.9/10万之间。东南亚、南非发病率在30/10万左右。而移居到美国华人肝癌发病率仍在12～18/10万,明显高于当地白人的2.9/10万,黑人的3.9/10万,更多还原

【Abstract】 The ’threshold model’ is most widely used for the study of multifactorial inheritance.According to this model, 212 cases of primary liver cancer clinically confirmed fromJanuary to June, 1984 in Shanghai and their 1742 first-degree relatives were in vestigatedby means of genetic epidemiological study. 56 cases of primary liver cancer were found inthese relatives. The controls were 209 normal persons selected to match the patients in sexand age (± 5 years) from the same area where the patients live. The controls have 1719first-degree relatives with 3 cases of liver cancer. The heritability for primary liver canceris estimated to be 66.7±3.57%. These results showed that genetic factors play an important role in the liability toprimary liver cancer. It is considered that primary liver cancer can be attributed to multi-factorial inheritance.更多还原