【摘要】 <正> 姐妹染色单体交换率(SCE)的检测,不仅被广泛应用于环境致癌因子的分析,而且可作为染色体不稳定性疾病和癌症易感性的细胞遗传学指标。本文介绍低浓度AFP阳性对象(简称低甲胎对象)外周血淋巴细胞的SCE检测结果,并对其作为肝癌高危险人群的监护价值作初步探讨。更多还原

【Abstract】 The frequencies of Sister Chromatid Exchange (SCE) have been studied in patients with primary hepatocarcinoma (PHC), chronic hepatitis(CH), low AFP cases(LAC) andhealthy controls. The SCE frequencies were found to be 0.1690±0.022, 0.1374±0.023, 0.1235±0.012,and 0.1003±0.014, in PHC, LAC, CH and controls, respectively. The propertions of cells which showing numbers of SCE, again demonstrate a cleardifference in the distribution between the groups of LAC and healthy controls groups. This preliminary study indicates the possibility of using SCE as a genetic marker forhigh risk persons of PHC.更多还原