【摘要】 <正> 1978年Goldenberg氏等应用¹³¹碘标记抗癌胚抗原（CEA）抗体（放射免疫探测法）对人体CEA分泌性肿瘤的定位诊断首先获得成功。此后,相继应用¹³¹碘标记抗甲胎蛋白（AFP）抗体、抗绒毛膜促性腺激素（HCG）抗体、以及抗前列腺酸性磷酸酶（PAP）抗体,分别作为AFP分泌性肿瘤、更多还原

【Abstract】 Eight patients were studied with radioimmunodetection using ¹³¹I-labelled antibody to AFP for the detection and localization of AFP secreting tumors. Seven of these patientshad primary hepatocellular carcinoma （PHC） and one patient had malignant lymphoma.The serum AFP levels in these patients ranged from 150 to 35,000 ng/ml. Intrahepaticlesion could be detected in 6 of 8 patients on immunoscintigraphy. The successful applica-tion of this method depends mainly on the purity of AFP antibody, the labelling proce-dure and the combined use of γ-scintiscan with computer subtraction technique. In com-parsion with radioisotopic liver scanning, ultrasonic B scanning and computed tomo-graphy, radioimmunodetection has been demonstrated to be a new and useful method for thedetection and localization of PHC and other tumors secreting AFP. As a result of furtherstudy AFP antibody carrying antitumor drugs might be anticipated to be a selectivetreat-ment for PHC in the near future.更多还原