【摘要】 <正> 近年来,由于短期生物测试的发展,国外对染发剂的致癌、致突变、致畸变研究日益增多。Chester Beatty癌症研究所和加利福尼亚大学的学者们发现许多染发药水都能损害鼠伤寒沙门氏菌的遗传物质DNA。Ames氏实验室的结论认为85％的氧化型染发剂具有致突变作用。然而,染发剂的微核试验国外未获得肯定的阳性结果;国内尚未见到有关研究报道。我们参照Matter和Schmid等的微核试验方法,用“上海染发剂”对小鼠进引了微核试验。现将试验方法与主要结果报道如下:更多还原

【Abstract】 The potential mutagenic effect of the commercial product of hair dye (p-Phenylenedi-amine type, "Shanghai Hair Dye" ) was examined with the micronucleus assay of the poly-chromatic erythrocytes of the bone marrow in mice. The results indicated that the hair dyeexhibited strong positive effect by both intraperitoneal injection and skin application, and a definite dose-response relationship was exhibited with intraperitoneal injection. The signi-ficance of the test and the comparison of present results with those reported in other coun-tries are discussed.更多还原