【摘要】 <正> 我们曾报告了消旋17-苯-18,19,20-失三碳PGF₂a甲酯（lA）及其15-差向异构体（1B）的合成[1]、[1A)对小鼠抗生育活性已大大超过其母体化合物PGF₂α,与15-甲基PGF₂a甲酯（IC）不相上下[2]。[1A]与（1A）与（1C）不更多还原

【Abstract】 Synthesis of d, 1-15-methy1-17-phenyl-18,19,20-trinorprostaglandin F2α methyl ester (6A) and its 15-epimer (6B) was reported.A mixture of (6A) and (6B) was obtained via a 4-step process,starting from α,β-unsaturated ketone( 2 ), with a total yield of 29%. The mixture was separated and purified with column chromatography on silica gel, to give(6A) and (6B) . Contrary to the usual manner, the Rf values of (3A) and (3B) on silica gel TLC were in the reversed order. Preliminary bioassay showed that (6A) and (6B) exhibited antifertility effect for terminating first trimester pregnancy in mice with a fertility rate of 10 and 60% respectively at a dose of 15/μ g/mouse S.C at days 6,7 and 8 of pregnany.更多还原