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硫代乙酰胺对接种的癌前变异肝细胞生长的促进作用

Promotive Effect of Thioacetamide on Growth of Transplanted Preneoplastic Hepatocytes

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【作者】 谭小弟; 丁濂; 王娟谭; 王淑华; 张连惠; 杨志刚;

【Author】 Tan Xiaodi, Ding Lian, Wang Juantan, Wang Shuhua, Zhang Lianhui and Yang Zhigang(Institute of Basic Medical Sciences, Beijing)

【机构】 基础医学研究所病理室; 基础医学研究所病理室 北京; 北京; 北京;

【摘要】 将DEN启动的SDN:SD大鼠肝细胞接种于同种大鼠肝后给以3周0.02%TAA饮水,可以促进接种的癌前变异肝细胞生长。

【Abstract】 Transplantation of hepatocytes isolated from diethylnitrosamine initiated SDN : SD rats to syngeneic animals was performed by Laishes method. After inoculation of hepatocytes, the experimental host rats were fed with 0.02% thioacetamide drinking water for 3 weeks. Four weeks after ceasation of thioacetamide treatment,there were more γ-GT positive liver cell foci (areas) developed in the experimental animals than that of the control.This result indicated that thioacetamide revealed a promotive effect on the growth of inoculated preneoplastic hepatocytes in rats.

  • 【文献出处】 中国医学科学院学报 ,Acta Academiae Medicinae Sinicae , 编辑部邮箱 ,1985年02期
  • 【被引频次】2
  • 【下载频次】13
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