【摘要】 <正> 哺乳类动物脑内发现特异的、高亲和力的BZ受体是近年来神经科学领域中的一项重要进展。迄今的大量研究提示,BZ受体存在种属差异,研究不同种属中BZ受体的特性,有助于阐明其生物学功能。本文应用放射配基受体结合分析法研究家兔脑内BZ受体的特性、分布及与GABA受体的关系。更多还原

【Abstract】 The characteristics and the regional and Subcellular distributions of benzodiazepine receptors in rabbit central nervous System(CNS) have been studied with [3H]-Flunitrazepam ([3H]FNP) binding. The results indicate that the distribution of benzodiazepine receptors in rabbit CNS is not uniform, i.e. the frontalcortex and hippocampus are the highest density areas and the Spinal cord the lowest.Benzodiazepine receptors are mainly located In the cell membrane and likely an acidic proteins which are heat-stablep. The receptors have a high specificity because 15 kinds of neutotravsmetters or other agonists and antagonists have no inhibitive effect on[3H]FNP binding. But GABA, muscimol stimulate the binding and bicuculline, picrotoxin abolish this stimulation. The pharmacological significance of benzodiazepine receptors has been discussed.更多还原