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新鱼腥草素对小鼠艾氏腹水癌的作用及癌细胞内c-AMP水平影响的研究

The Effect of Neo-huttuyninum on Ehrlich Ascites Cancer in Mice and on the Levels of c-AMP in These Tumor Cells in Vivo

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【作者】 陈炳生曾熙兰刘秀琴简志瀚杨惠玲潘伟雄

【Author】 Chen Bingsheng Zeng Xilan Liu Xiugin (Department of Nuclear Medicine, Zhongshan Medical College)Jian Zhihan Yang Huiling Pan weixiong (Department of Pathoyhpsiology, Zhongshan Medical College)

【机构】 中山医科大学核医学教研组中山医科大学病理生理教研组中山医科大学病理生理教研组

【摘要】 <正> 腹水测量:将处死的小白鼠称重后,剖腹取出腹水于刻度试管内,并用干棉球将剩下的腹水吸干称重,取腹水前鼠重减去取腹水后鼠重,即该鼠的腹水量。癌细胞总数测定:按常规用白细胞计数器计数(腹水经过一定稀释倍数以后计数),求算出每只小鼠癌细胞总数,并根据给药组与对照组的比较算出抑制率。

【Abstract】 In the recent study, the effect of Neo-Huttuyninum on the growth of Ehrlich ascites cancer in mice and the level of c-AMP in these tumor cells in vivo were investigated.The results showed that the quantity of ascite, the total tumor cells and the index of mitosis of tumor cells were marked decreased, but the levels of c-AMP in the Ehrlich tumor cells were elevated after the administration of Neo-Huttuyninum in different doses and at different time, the experiment of C group (0.34mg/10mg body.wt) showed that Neo-Huttuyninum has an obvious effect on the above mentioned index.The results suggested that the inhibitory effect of Neo-Huttuyninum on the Ehrlicn ascites cancer cells may be related the elevated leveis on c-AMP in the tumor cells.

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