【摘要】 <正> 腺病毒肺炎是危害我国小儿生命的主要疾病之一,目前尚无特异的药物治疗方法。过去我校儿科曾试用抗3、7型腺病毒的马血清来治疗,虽有一定的效果,但有明显的血清反应。如果使用高亲和力的单克隆中和抗体,预料不仅可以提高疗效,而且可以减少抗体用量,减轻血清反应。由于抗某型腺病毒单克隆中和抗体不能中和其他型的腺更多还原

【Abstract】 Eight hybridomas secreting monoclonal antibodies against adenovirus have been obtained.Among them four secrete groupspecific antibodies against adenovirus type 3, two secrete typespecific neutralization antibodies against adenovirus type 3, another two secrete type-specificneutralization antibodies against adenovirus type 7. Their application value and some technicproblems relevant to the preparation of hybridomas were discussed. In this country or abroad this was the first report about type-specific neutralization mono-clonal antibodies against adenovirus type 3 or type 7. To immune mice with alive adenovirusmay be the key point to get success. A screening technique of immune enzymatic histochemistry using three antigens has beendeveloped. It can detect antibodies and their specificity accurately and rapidly.更多还原