【摘要】 争光霉素是一种抗肿瘤抗生素。争光霉素A₆能抑制小鼠腹水肝癌细胞(H₂₂)的DNA、RNA和蛋白质的生物合成。对DNA合成的影响比对RNA及蛋白质合成的影响显著得多。实验结果表明,³H-TdR,³H-UR及³H-Leu的掺入抑制率,在一定范围之内随药物浓度的增加而上升。然而此药对正常小鼠骨髓细胞生物大分子的合成则概不抑制。争光霉素A₆对肿瘤细胞的选择性作用,无疑地会提高其在临床使用上的价值。更多还原

【Abstract】 Bleomycins are antibiotics which have antitumour and antibacterial activities. The effects of bleomycins A6 on macromolecular biosynthesis in mouse aseites hepatoma cells were studied. The,bleomyein A6 were observed to inhibit DNA,RNA and protein biosynthesis. DNA synthesis was more profoundly affected than RNA and protein synthesis The results indicated that the inhibition ratio was more marked with the high bleomyein A6 concentrations. However, the effect of bleomyein A6 on macromolec-ular synthesis showed a highly significant difference between the mouse aseites hepatoma cells and marrow cells of normal mouse. Under the action of higher concentration bleomyein A6 (250~500μg/ml), the incroporation of 3H-TdR into DNA, 3H-UR into RNA and that of 3H-Leucine into protein were riot signified by bleomyein A6 in marrow cells of normal mouse. The selective inhibitor of bleomyein A6 on tumor cells is very valuable on the clinical practice.更多还原